August 26, 2022

Improving prognosis and quality of life of young CRC patients: Tertiary prevention via multi-mar­ker models and nutritional interventions

Colorectal cancer (CRC) is increasing in younger individuals and depicts an o­verall five-year sur­vival rate reaching 65% with a recurrence rate about 10-40%. It is known that lifestyle fac­tors such as nutrition are important risk factors. The overriding goal of OUT­LI­VE-CRC is prevention or early detection of recurrences to improve prog­no­sis and quality of life of young CRC patients (< 50 years) by combining func­ti­onal ge­nomics and socio-me­di­cal ap­proaches. We will develop a biologi­cal age (BA) based multi-mar­ker risk panel encom­pas­sing cli­ni­cal para­me­ters as well as multi-omics data in blood and stool samples. Liquid biopsy tech­ni­ques will be applied to detect recurrence at early stage and be combined with BA mar­kers, u­sing ar­tificial intelligence methods. Mi­crofluidic automa­tion stra­tegies for transla­tion of the i­den­ti­fi­ed mul­ti-mar­ker panel into a point-of-care microfluidic plat­form will be studied. Nutritio­nal in­ter­venti­ons will be developed including endos­copy aiming the ge­ne­ration of personalized colo­nic 3D-or­ga­no­ids. Fi­nally, OUTLIVE-CRC will pro­vide a new tertiary pre­ven­tion concept for the young by com­bining li­quid biopsy tes­ting and nutriti­onal in­terventions. The consortium will be guided by cen­tral da­ta struc­tures and con­se­quent patient participation.

Coordinators of the network:

Dr. rer. nat. Stefanie Derer, Institute of Nutritional Medicine, +49-451-31018402, Stefanie.Derer@­

Prof. Dr. med. Nikolas von Bubnoff, Department of Hematology and Oncology, +49-451-50044151,

University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany