Improving prognosis and quality of life of young CRC patients: Tertiary prevention via multi-marker models and nutritional interventions
Colorectal cancer (CRC) is increasing in younger individuals and depicts an overall five-year survival rate reaching 65% with a recurrence rate about 10-40%. It is known that lifestyle factors such as nutrition are important risk factors. The overriding goal of OUTLIVE-CRC is prevention or early detection of recurrences to improve prognosis and quality of life of young CRC patients (< 50 years) by combining functional genomics and socio-medical approaches. We will develop a biological age (BA) based multi-marker risk panel encompassing clinical parameters as well as multi-omics data in blood and stool samples. Liquid biopsy techniques will be applied to detect recurrence at early stage and be combined with BA markers, using artificial intelligence methods. Microfluidic automation strategies for translation of the identified multi-marker panel into a point-of-care microfluidic platform will be studied. Nutritional interventions will be developed including endoscopy aiming the generation of personalized colonic 3D-organoids. Finally, OUTLIVE-CRC will provide a new tertiary prevention concept for the young by combining liquid biopsy testing and nutritional interventions. The consortium will be guided by central data structures and consequent patient participation.
Coordinators of the network:
Dr. rer. nat. Stefanie Derer, Institute of Nutritional Medicine, +49-451-31018402, Stefanie.Derer@uksh.de
Prof. Dr. med. Nikolas von Bubnoff, Department of Hematology and Oncology, +49-451-50044151, Nikolas.vonBubnoff@uksh.de
University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany